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LSM3235 

EPIGENETICS IN HUMAN HEALTH AND DISEASES
   2018/2019, Semester 1
   Yong Loo Lin School of Medicine (Physiology)
Modular Credits: 4
  Tags: --

Learning Outcomes

TopThis module introduces the concept of epigenetics, the relationship between the genome and the epigenome, and the translational aspects of epigenetics in relation to human health and diseases. The topics that will be covered include epigenetic variation, genomic technologies to study epigenetics, epigenetics in development, epimedicine, epigenetics in human diseases and epigenetics in ageing.

Prerequisites

TopLSM2232

Schedule

Top

TIMETABLE FOR SEMESTER I, 2018/2019

 

                                                                 LSM3235 –EPIGENETICS IN HUMAN HEALTH AND DISEASES

Module Coordinator: Dr Karthik Mallilankaraman

Email: phsmkb@nus.edu.sg

    Tel: 6516 4227

 

Lectures:

Mondays

Lectures:

Fridays

Time:

0800 – 1000 hrs

Time:

1000 – 1200 hrs

Venue:

LT21

Venue:

LT32

 

Wk

Month

Lectures / Tutorials

Lectures / Tutorials

Mondays, 8-10am, LT21

 

Fridays, 10-12nn, LT32

 

Orientation Week: Mon, 6 Aug – Sat, 11 Aug 2018 (No lecture)

1.      

Aug

13 Introduction to Epigenetics (KM)

17 DNA Methylation (SJ)

2.      

 

20 Writers, readers and erasers of epigenetic code (ESC)

24 Molecular machines involved in maintaining epigenetic code (SJ)

3.      

 

 

31 Tutorial 1 – (SJ)

4.      

Sep

03 Epigenetics in development (WWT)

07 Epigenetics in Heart and Related Diseases (WWT)

5.      

 

10 Tutorial 2 –  (WWT/KM)

14

6.      

 

17 Self directed learning (SDL) - Introduction (KM)

21 Epigenetics in metabolic diseases (WWT)

 

Recess Week: Sat, 22 Sep – Sun, 30 Sep 2018 (1 week)

7.      

Oct

01 Mitochondrial Epigenetics (KM)

05 CA1 (KM)

8.      

 

08 Mitochondrial Epigenetics in disease (KM)

12 Self directed learning (SDL)

9.      

 

15 Epigenetics in Brain and Related Diseases (KM)

19 Environmental influences on Epigenome (WWT)

10.   

 

22 Epigenetics in ageing (KM)

26 Self directed learning (SDL)

11.   

Oct/Nov

29 Tutorial 3 – Group 1 (KM/WWT)

02

12.   

Nov

05 Self directed learning (SDL)

09 Self directed learning (SDL)

13.   

 

12 SDL report due

16

 

Reading Week: Sat, 17 Nov – Fri, 23 Nov 2018 (1 week)

 

Examination:  Tue, 27 Nov 2018  1:00 pm

 

Vacation: Sun, 9 Dec 2018 – Sun, 13 Jan 2019 (5 weeks)

 

Mode of Assessment: 10% CA (report based on SDL), 10% Tutorial participation, 30% CA1 (MEQs - answer 3/5 questions), 50% Final Exam (MCQs)

 

Lecturers:

Dr Karthik Mallilankaraman (KM)

Dr Tee Wee Wei (WWT)

Dr Sudhakar Jha (SJ)

Dr Chen Ee Sin (ESC)

 

Syllabus

Top

SEMESTER I

LSM3235 EPIGENETICS IN HUMAN HEALTH AND DISEASES

 

 

Prerequisite: LSM2232

Workload: 24 lecture hours + 12 tutorial hours + 14 SDL/CA hours

This module introduces the concept of epigenetics, the relationship between the genome and the epigenome, and the translational aspects of epigenetics in relation to human health and diseases. The topics that will be covered include epigenetic variation, genomic technologies to study epigenetics, epigenetics in development, epimedicine, epigenetics in human diseases and epigenetics in ageing.

 

 

S/N

Topics

Lecture hours

 

Molecular basis of Epigenetics

 

 

Introduction to Epigenetics

2h (KM)

 

DNA Methylation

2h (SJ)

 

Writers, readers and erasers of epigenetic code

2h (ESC)

 

Molecular machines involved in maintaining epigenetic code

2h  (SJ)

 

Translational Epigenetics

 

 

Epigenetics in development

2h (WWT)

 

Epigenetics in Heart and Related Diseases

2h (WWT)

 

Epigenetics in metabolic diseases

2 h (WWT)

 

Epigenetics in Brain and Related Diseases

2h (KM)

 

Epigenetics in ageing

2h (KM)

 

Environmental influences on Epigenome

2h (WWT)

 

Mitochondrial Epigenetics

2h ( KM )

 

Mitochondrial Epigenetics in disease

2h (KM)

 

Total Lectures: 24

Tutorials: 12

SDL/CA: 14

 

 

Total hours: 50

 

TEXT BOOK: The readings will mainly be based on key scientific papers & review articles. The module has three major themes. At the end of each major theme, the students will be given stellar publications related to the thematic area they learned in the class.

 

MODE OF ASSESSMENT: CA 50%; Final exam: 50%

 

MODULE CO-ORDINATOR:

Dr. Karthik Mallilankaraman      (Tel: 6516-4227, E-mail: phsmkb@nus.edu.sg)

 

LECTURERS:

 

Dr. Karthik Mallilankaraman, Physiology (KM, Physiology)

Dr Tee Wee Wei, Physiology (WWT)

Dr. Sudhakar Jha, Biochemistry (SJ)

Dr Chen Ee Sin (ESC)

Assessment

Top10% CA (report based on SDL), 10% Tutorial participation, 30% CA1 (MEQs - answer 3/5 questions), 50% Final Exam (MCQs)

Workload

Top

 

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