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Learning Outcomes

TopThis module introduces the concept of epigenetics, the relationship between the genome and the epigenome, and the translational aspects of epigenetics in relation to human health and diseases. The topics that will be covered include epigenetic variation, genomic technologies to study epigenetics, epigenetics in development, epimedicine, epigenetics in human diseases and epigenetics in ageing.

Prerequisites

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Schedule

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TIMETABLE FOR SEMESTER I, 2018/2019

LSM3235 –EPIGENETICS IN HUMAN HEALTH AND DISEASES

Module Coordinator: Dr Karthik Mallilankaraman

Email: phsmkb@nus.edu.sg

Tel: 6516 4227

Lectures:	Mondays	Lectures:	Fridays
Time:	0800 – 1000 hrs	Time:	1000 – 1200 hrs
Venue:	LT21	Venue:	LT32

Wk	Month	Lectures / Tutorials	Lectures / Tutorials
Wk	Month	Mondays, 8-10am, LT21	Fridays, 10-12nn, LT32
	Orientation Week: Mon, 6 Aug – Sat, 11 Aug 2018 (No lecture)
1.	Aug	13 Introduction to Epigenetics (KM)	17 DNA Methylation (SJ)
2.		20 Writers, readers and erasers of epigenetic code (ESC)	24 Molecular machines involved in maintaining epigenetic code (SJ)
3.			31 Tutorial 1 – (SJ)
4.	Sep	03 Epigenetics in development (WWT)	07 Epigenetics in Heart and Related Diseases (WWT)
5.		10 Tutorial 2 – (WWT/KM)	14
6.		17 Self directed learning (SDL) - Introduction (KM)	21 Epigenetics in metabolic diseases (WWT)
	Recess Week: Sat, 22 Sep – Sun, 30 Sep 2018 (1 week)
7.	Oct	01 Mitochondrial Epigenetics (KM)	05 CA1 (KM)
8.		08 Mitochondrial Epigenetics in disease (KM)	12 Self directed learning (SDL)
9.		15 Epigenetics in Brain and Related Diseases (KM)	19 Environmental influences on Epigenome (WWT)
10.		22 Epigenetics in ageing (KM)	26 Self directed learning (SDL)
11.	Oct/Nov	29 Tutorial 3 – Group 1 (KM/WWT)	02
12.	Nov	05 Self directed learning (SDL)	09 Self directed learning (SDL)
13.		12 SDL report due	16
	Reading Week: Sat, 17 Nov – Fri, 23 Nov 2018 (1 week)
	Examination: Tue, 27 Nov 2018 1:00 pm
	Vacation: Sun, 9 Dec 2018 – Sun, 13 Jan 2019 (5 weeks)

Mode of Assessment: 10% CA (report based on SDL), 10% Tutorial participation, 30% CA1 (MEQs - answer 3/5 questions), 50% Final Exam (MCQs)

Lecturers:

Dr Karthik Mallilankaraman (KM)

Dr Tee Wee Wei (WWT)

Dr Sudhakar Jha (SJ)

Dr Chen Ee Sin (ESC)

Syllabus

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SEMESTER I

LSM3235 EPIGENETICS IN HUMAN HEALTH AND DISEASES

Prerequisite: LSM2232

Workload: 24 lecture hours + 12 tutorial hours + 14 SDL/CA hours

This module introduces the concept of epigenetics, the relationship between the genome and the epigenome, and the translational aspects of epigenetics in relation to human health and diseases. The topics that will be covered include epigenetic variation, genomic technologies to study epigenetics, epigenetics in development, epimedicine, epigenetics in human diseases and epigenetics in ageing.

S/N		Topics	Lecture hours
	Molecular basis of Epigenetics
	Introduction to Epigenetics		2h (KM)
	DNA Methylation		2h (SJ)
	Writers, readers and erasers of epigenetic code		2h (ESC)
	Molecular machines involved in maintaining epigenetic code		2h (SJ)
	Translational Epigenetics
	Epigenetics in development		2h (WWT)
	Epigenetics in Heart and Related Diseases		2h (WWT)
	Epigenetics in metabolic diseases		2 h (WWT)
	Epigenetics in Brain and Related Diseases		2h (KM)
	Epigenetics in ageing		2h (KM)
	Environmental influences on Epigenome		2h (WWT)
	Mitochondrial Epigenetics		2h ( KM )
	Mitochondrial Epigenetics in disease		2h (KM)
Total Lectures: 24 Tutorials: 12 SDL/CA: 14
		Total hours: 50

TEXT BOOK: The readings will mainly be based on key scientific papers & review articles. The module has three major themes. At the end of each major theme, the students will be given stellar publications related to the thematic area they learned in the class.