2011/2012, Semester 2
Yong Loo Lin School of Medicine (Microbiology & Immunology)
Modular Credits: 4
This course provides the central concepts of immunology and the foundation for understanding how immunity functions. The subjects of innate immunity and haematopoiesis introduce the origin and role of different cell types in immunity. The mechanics of how the body protects itself from diseases are explored in relation to T and B cell biology, antibody-antigen interactions, major histocompatibility complex and antigen presentation. Other topics include hypersensitivity, immunodeficiencies, immune tolerance, autoimmunity, resistance and immunization to infectious diseases.
Lecture + Laboratory + Tutorial
TIMETABLE FOR SEMESTER II, 2011/2012
Module Coordinator: Dr Paul Macary
THURSDAYS (EVEN WEEKS)
1200 – 1400 hrs
1200 – 1800 hrs
LS LAB 9 MD4 LEVEL 4
*Practicals alternate with LSM3232 andLSM3221 (ODD WEEKS)
THURSDAYS (EVEN WEEKS)
13. Overview of Immunology. Cells and
Structures of the immune system.
20. Antigens. Innate immunity
27. Immunoglobulin structure and function.
03. Antibody-antigen interactions.
2* Practical 1 : Cells of the immune
system plus antigens and antibodies.
10. Antigen Processing/Presentation I.
Antigen Processing/Presentation II.
17. Generation of immunoglobulin and
T-cell receptor diversity.
Major Histocompatibility Complex.
Recess week :
Sat 18 Feb – Sun 2
02. Cytokines and chemokines.
T-cell development and activation.
09. Cell-mediated immunity: T-cell subsets;
Adaptive immunity. Hypersensitivity I.
8* CA (Lecture Topics 1 – 12).
(2.30 – 3.30 pm, venue: LS.Lab.9).
16. Viruses and parasites.
Bacteria and fungi.
23. Immunological tolerance.
22*Practical 2:Cell-mediated immunity:
Elispot, flow cytometry etc.
Tutorial 2 : Post-test review, Q & A
30. Tumour immunology.
06 Public Holiday
5* Practical 3 : Enzyme-linked immuno
Sorbent assay and immunoblot.
Vaccines and immunisation.
READING PERIOD : Sat 14
Apr to Fri
VACATION : Sun 0
Aug 2012 (13 weeks)
Lecturers: Dr Paul Macary (Module Coordinator)
Prof Kemeny D Michael
A/P Lu Jinhua
Mode of assessment
Continuous Assessment (CA) MCQ = 30%
Final Examination = 70%
Workload Components : A-B-C-D-E
A: no. of lecture hours per week
B: no. of tutorial hours per week
C: no. of lab hours per week
D: no. of hours for projects, assignments, fieldwork etc per week
E: no. of hours for preparatory work by a student per week