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Module Overview


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LSM4213 

Systems Neurobiology
   2018/2019, Semester 1
   Yong Loo Lin School of Medicine (Physiology)
Modular Credits: 4
  Tags: --

Learning Outcomes

Top

The primary goal of this module is to understand (a) how neurons, assembled into circuits, mediate behavior and (b) how technology can remediate neural dysfunction by affecting the circuits.

This course draws on basic knowledge of the cell biology and physiology of neurons.

Prerequisites

TopFormal prerequisites: LSM3215 and LSM3216

Students who have received permission to take LSM4213, but who have not taken the formal prerequisites are responsible for self-studying the required background material.  There are many good resources one can use for such self-study; for example, one may use Chapters 2-7, 25 and 31 of the Neuroscience textbook (2nd edition) by Purves and colleagues which can be browsed online https://www.ncbi.nlm.nih.gov/books/NBK10799; or Section 1, Chapters 1-8 and Section 4, Chapter 7 of the Neuroscience Online textbook from the Department of Neurobiology and Anatomy at the McGovern Medical School of The University of Texas Health Science Center at Houston which can be read online at https://nba.uth.tmc.edu/neuroscience/.

Teaching Modes

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Lectures, practical, tutorials, and self-directed learning (SDL)

Syllabus

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S/N Topics Proposed Lectures

 
Sensation and motor behaviour
1. Functional neuroanatomy (2hr)

2. General scheme of sensory processing (2hr)
3. Somatosensation and pain (2hr)
4. Basis of vision (2hrs)
5. Organizational features of motor processing (2hr)
 
10 hr
Sanjay Khanna
 

 
Higher brain functions and synaptic plasticity
6. Object recognition: edge detection and simple forms (2 hr)

7. Object recognition: complex objects, face recognition and beyond (2 hr)
8. Memory (2 hr)
9. Memory and goal directed behaviour (2 hr)
10. Neural basis of working memory (2 hr)
11. Developmental plasticity in vision (2 hr)
12-13. Plasticity and simple motor learning (4 hr)
 
16 hr
Andrew Tan
Fu Yu
 
 

 
Neurotechnology
14. Parkinson’s disease and deep brain stimulation (2 hr)

15. Tetraplegia and brain-machine interfaces (2 hr)
16. Practical: muscle-machine interface (4 hr)
 
4 hr + 4 hr
Andrew Tan
Wong Boon Seng
 
 
Total Lectures: 30 hrs
Practical: 4 hrs
Tutorials: 8 hrs

SDLs: 8 hrs
 
Total hours:
 
 
50h
 

Schedule

TopTIMETABLE FOR SEMESTER I, 2018/2019
 
LSM4213-SYSTEMS NEUROBIOLOGY
Module Coordinator: Andrew Tan Yong-Yi
 
LECTURES /TUTORIALS: Monday Wednesday
TIME: 1000 - 1200 hrs 1400 - 1600 hrs
VENUE (LECTURES/TUTORIALS): LT32 LT34
     
VENUE (PRACTICALS): M14 [Behind LT28]  
 
WK MONTH MONDAYS
10 am - 12 noon
WEDNESDAYS
2 pm - 4 pm
  1.  
Aug 13 Lecture 1 (SK) 15 Lecture 2 (SK)
  1.  
Aug 20 Lecture 3 (SK) 22 Hari Raya Haji
  1.  
Aug 27 Lecture 4 (SK) 29 Lecture 5 (SK)
  1.  
Sep 03 No Class 05 No Class
  1.  
Sep 10 Lecture 6 (AT) (SDL1 due) 12 Lecture 7 (AT)
  1.  
Sep 17 Lecture 8 (AT)  19 Lecture 9 (AT)
Recess week: Sat 22 Sep – Sun 30 Sep 2018  (1 week)
  1.  
Oct 01 Lecture 10 (AT) 03 Lecture 11 (AT)
  1.  
Oct 08 Lecture 12 (AT) 10 Lecture 13 (FY)
  1.  
Oct 15 No Class 17 No Class
  1.  
Oct 22 Lecture 14 (AT) (SDL2 due) 24 Lecture 15 (AT) (BS)
  1.  
Oct 29 Practical - Group 1 (BS) 31 Tutorial 1 (SK)
(Practical Report - Group 1 due)
  1.  
Nov 05 Practical - Group 2 (BS) 07 Tutorial 2 (SK)
(Practical Report - Group 2 due)
  1.  
Nov 12 Tutorial 3 (AT) 14 Tutorial 4 (AT)
READING PERIOD : Sat 17 Nov – Fri 23 Nov 2018 (1 week)
EXAMINATION: Mon 3 Dec 2018, 5:00 pm
VACATION : Sun 9 Dec 2018 – Sun 13 Jan 2019 (5 weeks)
 
Assignments Submission Dates:
SDL1 due on 10 Sep 2018
SDL2 due on 22 Oct 2018
Practical Report - Group 1 due on 31 Oct 2018
Practical Report - Group 2 due on 07 Nov 2018
 
Lecturers:
Dr. Andrew Tan Yong-Yi (AT)  phstya@nus.edu.sg 65165955
A/Prof Sanjay Khanna (SK)  phsks@nus.edu.sg 65163665
Dr. Fu Yu (FY)     fu_yu@sbic.a-star.edu.sg     64788764
Dr. Wong Boon Seng (WBS)   boon_seng_wong@nuhs.edu.sg  67728283
                                                                                
                                               
                       

Assessment

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Continuous assessment (CA) = 45% (2 SDLs - 22.5% per SDL)
Final exam = 55%

SDL
2 SDL reports
Each SDL contributes 22.5% of the total marks
Both SDLs together contribute 45% of the total marks
The due date for each SDL is indicated on the time table
Font size (10 – 12)
Typewritten (3 pages – excluding references)
Single-sided (with 1.5 – double space)
Penalty for Late Submission – 1% of the total marks, per calendar day overdue

SDL1

Individual submission

SDL2
Individual submission

Final Exam
The final exam contributes 55% of the total marks.
The date and time of the final exam are indicated on the time table

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