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Module Overview


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LSM4211 

TOXICOLOGY
   2007/2008, Semester 1
   Yong Loo Lin School of Medicine (Pharmacology)
Modular Credits: --
  Tags: --

Learning Outcomes

TopThis introductory course is aimed at providing the basic principles and modern concepts of toxicology ? adverse effects of chemicals on humans and the biosphere. The students will understand how to make quantitative risk assessments from exposure to hazardous compounds, how to extrapolate from animal data, and how to link adverse effects at the molecular level to overall toxic responses in humans. Lecture topics include health hazards from drugs, naturally occurring toxins, industrial chemicals, or environmental toxicants; toxicokinetics and toxicodynamics; cellular and molecular mechanisms of toxicity; organ-selective toxicity; and safety evaluation of drugs and other chemicals. The general concepts will be illustrated with a number of both classical and highly topical examples.

Syllabus

Top

 

Lectures/Tutorial:  Days – Monday 12-2pm (2h)                   Venue: LT20                                                     

Thursday 12-2pm (2h)                   

 

Lecturer:              A/P Madhav Bhatia

                                A/P Shabbir Moocchhala

               Prof. Ong Choon Nam

                                Dr. Shen Han-Ming

 

Day

Date

Topic

*Venue

Lecturer

Mon

13.8.07

L1

Introduction

 

MB

Thu

16.8.07

L2

Mechanistic Toxicology

 

SHM

Mon

20.8.07

L3

Toxicodynamics

 

SMM

Thu

23.8.07

L4

Toxicokinetics

 

SMM

Mon

27.8.07

L5

Chemical mutagenesis and carcinogenesis: Genotoxicity

 

SMM

Thu

30.8.07

L6

Carcinogenesis

 

SMM

Mon

3.9.07

L7

Acute, Sub-acute and Chronic Toxicology

 

SMM

Thu

6.9.07

PBL1

 

 

SMM

Mon

10.9.07

PBL1

 

 

SMM

Thu

13.9.07

L8

Organ-selective toxicity

 

MB

Mon

17.9.07

L9

Hepatotoxicity

 

SHM

Thu

20.9.07

L10

Neurotoxicity

 

SMM

Mon

24.9.07

PBL2

 

 

SHM

Thu

27.9.07

PBL2

 

 

SHM

Mon

1.10.07

L11

Pulmonary and Inhalational Toxicity

 

MB

Thu

4.10.07

PBL3

 

 

MB

Mon

8.10.07

PBL3

 

 

MB

Thu

11.10.07

L12

Environmental Toxicology

 

OCN

Mon

15.10.07

L13

Environmental carcinogens

 

OCN

Thu

18.10.07

PBL4

 

 

OCN

Mon

22.10.07

PBL4

 

 

OCN

Thu

25.10.07

 

*Revision

 

 

 

 

 

 

 

 

*any question for revision must be submitted to the lecturer 4 days before the revision date

 

……./2

 

 

 

 

Mon

29.10.07

 

Self study

 

 

Thu

1.11.07

 

Tutorial / Feedback PBLs

 

 

Mon

5.11.07

 

Self study

 

 

Mon

12.11.07

 

Q & A**

 

All

 

 

 

Reading Week

 

 

Wed

28.11.07

 

Final Exam (1 pm)

 

 

*any question for revision must be submitted to the lecturer 4 days before the revision date

 

 

Assessment

Top

PBL                                             -        40%   (written report, group work)

Final Examination                 -        60%  (long Qs)

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