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LSM4212 

PHARMACOGENETICS AND DRUG RESPONSES
   2009/2010, Semester 1
   Yong Loo Lin School of Medicine (Pharmacology)
Modular Credits: 4
  Tags: --

Learning Outcomes

TopThis module addresses the genetic and non-genetic bases for drug response variability. It will review critical aspects of pharmacokinetics, pharmacodynamics, drug metabolism, drug transporters actions and pharmacogenetics. The focus of the module is on understanding rather than detailed factual content, and it is hoped the student will eventually develop an insight and the appropriate skill sets with respect to some of these areas of therapeutics and drug action.

Prerequisites

TopFor Life Sciences major. Students must pass LSM3211 or LSM3221.

Schedule

Top

Lectures: Mon (2.00pm – 4.00pm);  Thurs   (2.00pm – 4.00pm)                    

Venue:     LT 23          

 

Wks

Day

Date

Topic

1

Mon

3.8.09

Orientation week

 

Thurs

6.8.09

Orientation week

2

Mon

10.8.09

Public Holiday

 

Thurs

13.8.09

Add/Drop

3 

Mon

17.8.09

Introduction to Course

Drug Response - Mechanisms of Efficacy, Toxicity

 

Thurs

20.8.09

Essential Pharmacokinetics

4

Mon

24.8.09

Pharmacokinetic Variability 

 

Thurs

27.8.09

Introduction to Pharmacogenetics

Identifying Pharmacogenetic Problems

5

Mon

31.8.09

Non- Genetic Factors

 

Thurs

3.9.09

Race/Ethnicity/Population Issues

6

Mon

7.9.09

Drug Metabolism - Cause of Variability

Drug Distribution - Cause of Variability

 

Thurs

10.9.09

PK Case Study 1 - Group 1

PK Case Study 2 - Group 2

7

Mon

14.9.09

CA

 

Thurs

17.9.09

 

 

 

 

 

 

 

 

Recess (19/9/09 – 27/9/09)

8

Mon

28.9.09

CYP2C9/2C19/CYP2D6

 

Thurs

1.10.09

GST/UGT/TPMT

9 

Mon

5.10.09

Presentation and Discussion - Group 3/4

 

Thurs

8.10.09

Presentation and Discussion - Group 5/6

10

Mon

12.10.09

Self study

 

Thurs

15.10.09

Presentation and Discussion - Group 7/8

11

Mon

19.10.09

Presentation and Discussion - Group 9/10

 

Thurs

22.10.09

Presentation and Discussion - Group 11/12

12

Mon

26.10.09

Presentation and Discussion - Group 13/14

 

Thurs

29.10.09

 

 

 

 

(Reading Period: 27.10.09 – 25.11.09)

 

 

 

 

 

 

 

(Exam: 26.11.09)

Workload

Top2-1-0-2-5

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