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Learning Outcomes

TopThis module addresses the genetic and non-genetic bases for drug response variability. It will review critical aspects of pharmacokinetics, pharmacodynamics, drug metabolism, drug transporters actions and pharmacogenetics. The focus of the module is on understanding rather than detailed factual content, and it is hoped the student will eventually develop an insight and the appropriate skill sets with respect to some of these areas of therapeutics and drug action.

Prerequisites

TopFor Life Sciences major. Students must pass LSM3211 or LSM3221.

Schedule

Top

Lectures: Mon (2.00pm – 4.00pm); Thurs (2.00pm – 4.00pm)

Venue: LT 23

Wks	Day	Date	Topic
1	Mon	3.8.09	Orientation week
	Thurs	6.8.09	Orientation week
2	Mon	10.8.09	Public Holiday
	Thurs	13.8.09	Add/Drop
3	Mon	17.8.09	Introduction to Course Drug Response - Mechanisms of Efficacy, Toxicity
	Thurs	20.8.09	Essential Pharmacokinetics
4	Mon	24.8.09	Pharmacokinetic Variability
	Thurs	27.8.09	Introduction to Pharmacogenetics Identifying Pharmacogenetic Problems
5	Mon	31.8.09	Non- Genetic Factors
	Thurs	3.9.09	Race/Ethnicity/Population Issues
6	Mon	7.9.09	Drug Metabolism - Cause of Variability Drug Distribution - Cause of Variability
	Thurs	10.9.09	PK Case Study 1 - Group 1 PK Case Study 2 - Group 2
7	Mon	14.9.09	CA
	Thurs	17.9.09

			Recess (19/9/09 – 27/9/09)
8	Mon	28.9.09	CYP2C9/2C19/CYP2D6
	Thurs	1.10.09	GST/UGT/TPMT
9	Mon	5.10.09	Presentation and Discussion - Group 3/4
	Thurs	8.10.09	Presentation and Discussion - Group 5/6
10	Mon	12.10.09	Self study
	Thurs	15.10.09	Presentation and Discussion - Group 7/8
11	Mon	19.10.09	Presentation and Discussion - Group 9/10
	Thurs	22.10.09	Presentation and Discussion - Group 11/12
12	Mon	26.10.09	Presentation and Discussion - Group 13/14
	Thurs	29.10.09
			(Reading Period: 27.10.09 – 25.11.09)

			(Exam: 26.11.09)

Workload

Top2-1-0-2-5

Learning Outcomes

Prerequisites

Schedule

Wks

Day

Date

Race/Ethnicity/Population Issues

Drug Metabolism - Cause of Variability

PK Case Study 1 - Group 1

CA

Recess (19/9/09 – 27/9/09)

CYP2C9/2C19/CYP2D6

GST/UGT/TPMT

Presentation and Discussion - Group 3/4

Presentation and Discussion - Group 5/6

Self study

Workload