ADVANCED EPIDEMIOLOGY I
2017/2018, Semester 2
Saw Swee Hock School of Public Health (Saw Swee Hock School of Public Health)
Modular Credits: SPH5203 ( 4 ) / SPH6001 ( 4 )
This module will be conducted every Monday evening, 6pm to 9pm. Classes will commence on 15 January 2018.
For more information on topics and venues, please check the module schedule uploaded in the IVLE Files. Any changes to the schedule will be reflected in the module schedule.
Brief Module Description
This module covers advanced methods for the design, conduct, analysis and interpretation of epidemiologic studies. The main focus is on analytical studies that aim to identify risk factors for diseases particularly case-control and cohort studies. Topics include causal inference, study design, methods of handling confounding and identifying effect modification, measurement error and information bias, selection bias, lifestyle and molecular epidemiology, and meta-analysis.
Upon completion of this course, you will be able to:
Understand the strengths, limitations, and principles of different study designs including retrospective casecontrol, nested case-control, case-cohort, cohort, cross-sectional, and ecological studies and randomised controlled trials
Identify and interpret effect modification
Identify potential sources of selection and information bias, reverse causation and regression to the mean, judge how this may affect results, and understand how to control bias by appropriate study design
Identify potential sources of confounding and understand how to address confounding in the design and analysis of epidemiological studies
Explain commonly used considerations for causal inference and models of causality
Understand the concepts ‘validity’ and ‘precision’, ‘random’ and ‘systematic measurement error’, ‘differential’ and ‘non-differential misclassification’, and the use of validation and reproducibility studies for epidemiological research
Understand the general principles and strengths and limitations of systematic reviews and meta-analyses and be able to judge when these are useful
Understand the different steps of conducting a systematic review, causes of publication bias, and the importance of evaluating heterogeneity in study results and be able to interpret the main statistical measures and graphs used in meta-analyses
Understand major considerations specific to the design and interpretation of molecular epidemiology studies
Judge the quality of articles on epidemiological studies and be able to interpret from these articles
SPH5002 Public Health Research Methods; OR
CO5102 Principles of Epidemiology and CO5103 Quantitative Epidemiologic Methods
Critiques of Research Articles
This module will be offered in the second semester. The course consists of
Lectures and related class discussion/exercises.
Critiques of scientific articles that illustrate the application of important epidemiological concepts. Generally, the first part of the class will consistent of lectures and the second part of exercises or an article critique.
The development and oral presentation of a research proposal.
The course grade will be based on class participation, the student presentations prepared by groups of approximately 3 students, and the results of a closed-book exam:
Class Participation 10%
Student Presentation of Research Proposal 30%
Final Examination (Closed Book) 60%
When a student is unable to attend the required sessions, an excuse may be granted for limited time periods upon the production of evidence of illness, misadventure or leave of absence having been granted.
Students must inform the Education Office if any of the above has taken place.
Failure to meet attendance requirements will affect module grading.