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Learning Outcomes

TopThis module will explore the changes that occur in human cells as they grow, mature, differentiate, and either commit to cell death or renew themselves. Insights into the mechanisms that govern the various developmental alterations that occur will be discussed. Emphasis will be placed on understanding the cellular and molecular mechanisms that lend themselves to experimental manipulation.

Prerequisites

TopPrerequisite: LSM2103

Teaching Modes

TopLectures, Tutorials, Group Activity, Journal Discussions and Student Presentations

Syllabus

TopSEMESTER I
LSM4232 ADVANCED CELL BIOLOGY

Prerequisite: LSM2103
Workload: 30 lecture hours + 8 tutorial hours + 10 hours for CA, student presentations and revision
This module will explore the changes that occur in human cells as they grow, mature, differentiate, and either commit to cell death or renew themselves. Insights into the mechanisms that govern the various developmental alterations that occur will be discussed. Emphasis will be placed on understanding the cellular and molecular mechanisms that lend themselves to experimental manipulation.

S/N	Topics	Lecture Hrs
1.	Cell Dynamics Control Morphogenesis, Differentiation and Development Small GTPases and their regulators as major cellular switches Cytoskeletal networks Interplay in cell morphogenesis, cell motility, cell division, organogenesis and development	10 Low Boon Chuan
2.	Cell differentiation - mechanisms Embryonic and postnatal myogenesis Differentiation of skeletal muscle Stem cells and Notch signalling in adult myogenesis and ageing Muscle degeneration mechanisms in muscular dystrophies	8 Reshma Taneja
3.	WW Domain and Hippo-YAP Pathway	4 Marius Sudol
4.	Signalling and ROS in ageing and disease Oxidative stress and mitochondrial ageing DNA Proteins Regulation of cell death signalling Receptor and non-receptor death signalling ROS, KRAS and drug discovery	4 Shazib Pervaiz
	Total lectures (Including guest lecture) : 28h Tutorials : 6h CA, student presentations and revision : 18h
	Total hours:	52h

MAIN REFERENCES: Selected papers

SUPPLEMENTARY TEXT BOOKS:
(1) Genes VII (Lewin)
(2) Molecular Biology of the Cell (6^th Edition by Alberts, Johnson, Lewis, Morgan, Raff, Roberts & Walter; Publisher: Garland Science)
MODES OF ASSESSMENT:
50% CA (1 x short essay question test, 1 x student presentation)
50% Final Exam (60 x multiple choice questions, closed book)

MODULE COORDINATOR:
Dr. Chen Zhi Xiong                   (Tel: 6516-3231, Email: phscz@nus.edu.sg)

LECTURERS:
Assoc. Prof. Low Boon Chuan    (Tel: 6516-7834, Email: dbslowbc@nus.edu.sg)
Assoc. Prof. Reshma Taneja      (Tel: 6516-3236, Email: phsrt@nus.edu.sg)
Assoc. Prof. Marius Sudol          (Tel: 6516-5460, Email: phsms@nus.edu.sg)
Prof. Shazib Pervaiz                  (Tel: 6516-6602, Email: phssp@nus.edu.sg)

GUEST LECTURER:
Dr. Tsai Shih-Yin                       (Tel: 6516-7617, Email: phsts@nus.edu.sg)

Schedule

TopTIMETABLE FOR SEMESTER I, 2017/2018

LSM4232 – ADVANCED CELL BIOLOGY

Module Coordinator: Dr. Chen Zhi Xiong

LECTURES:	MONDAYS & THURSDAYS
TIME:	1200 – 1400 hrs
VENUE:	S1A-0217

WK	MONTH	LECTURES / TUTORIALS
WK	MONTH	MONDAYS	THURSDAYS
0.	Aug	Orientation Week - No classes (Mon, 7 Aug to Sat, 12 Aug 2017)
	Aug	14 LBC Lecture 1	17 LBC Lecture 2
		21 LBC Lecture 3	24 LBC Lecture 4
		28 LBC Lecture 5	31 LBC Journal Discussion
	Sep	04 LBC Journal Discussion	07 RT Lecture 1
		11 RT Lecture 2	14 RT Lecture 3
		18 RT Lecture 4	21 TS Guest Lecture
Recess week: Sat, 23 Sep – Sun, 1 Oct 2017 (1 week)
	Oct	02 LBC CA1	05 LBC CA1 Post Mortem
		09 RT Student Journal Presentation	12 RT Student Journal Presentation
		16 MS Lecture 1	19 MS Lecture 2
		23 MS Student Journal Presentation	26 MS Student Journal Presentation
	Oct/Nov	30 SP Lecture 1	02 SP Lecture 2
		06 SP Student Journal Presentation	09 SP Student Journal Presentation
		13 Self-Revision and Consultation	16 Self-Revision and Consultation
READING PERIOD: Sat, 18 Nov to Fri, 24 Nov 2017 (1 week)
EXAMINATION: Mon, 4 Dec 2017, 5pm
VACATION: Sun, 10 Dec 2017 to Sun, 14 Jan 2018 (5 weeks)

Lecturers:
Assoc. Prof. LOW Boon Chuan (dbslowbc@nus.edu.sg; Tel: 6516-7834) (LBC)
Assoc. Prof. Reshma TANEJA (phsrt@nus.edu.sg; Tel: 6516-3236) (RT)
Dr. TSAI Shih-Yin (phsts@nus.edu.sg; Tel: 6516-7617) (TS)
Assoc. Prof. Marius SUDOL (phsms@nus.edu.sg; Tel: 6516-5460) (MS)
Prof. Shazib PERVAIZ (phssp@nus.edu.sg; Tel: 6516-6602) (SP)

Coordinator:
Dr. CHEN Zhi Xiong (zhixiong_chen@nus.edu.sg; Tel: 6516-3231)

Assessment

Top

50% CA (1 x short essay question test, 1 x student presentation)
50% Final Exam (60 x multiple choice questions, closed book)