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LSM4232 

ADVANCED CELL BIOLOGY
   2017/2018, Semester 1
   Yong Loo Lin School of Medicine (Physiology)
Modular Credits: 4
  Tags: --

Learning Outcomes

TopThis module will explore the changes that occur in human cells as they grow, mature, differentiate, and either commit to cell death or renew themselves. Insights into the mechanisms that govern the various developmental alterations that occur will be discussed. Emphasis will be placed on understanding the cellular and molecular mechanisms that lend themselves to experimental manipulation.

Prerequisites

TopPrerequisite: LSM2103

Teaching Modes

TopLectures, Tutorials, Group Activity, Journal Discussions and Student Presentations

Syllabus

TopSEMESTER I
LSM4232 ADVANCED CELL BIOLOGY
 
Prerequisite:  LSM2103
Workload: 30 lecture hours + 8 tutorial hours + 10 hours for CA, student presentations and revision
This module will explore the changes that occur in human cells as they grow, mature, differentiate, and either commit to cell death or renew themselves. Insights into the mechanisms that govern the various developmental alterations that occur will be discussed. Emphasis will be placed on understanding the cellular and molecular mechanisms that lend themselves to experimental manipulation.
 
S/N Topics Lecture Hrs
1. Cell Dynamics Control
  • Morphogenesis, Differentiation and Development
  • Small GTPases and their regulators as major cellular switches
  • Cytoskeletal networks
    • Interplay in cell morphogenesis, cell motility, cell division, organogenesis and development
10
Low Boon Chuan
2. Cell differentiation - mechanisms
  • Embryonic and postnatal myogenesis
  • Differentiation of skeletal muscle
  • Stem cells and Notch signalling in adult myogenesis and ageing
  • Muscle degeneration mechanisms in muscular dystrophies
8
Reshma Taneja
3. WW Domain and Hippo-YAP Pathway 4
Marius Sudol
4. Signalling and ROS in ageing and disease
  • Oxidative stress and mitochondrial ageing
    • DNA
    • Proteins
  • Regulation of cell death signalling
    • Receptor and non-receptor death signalling
  • ROS, KRAS and drug discovery
4
Shazib Pervaiz
                                                            Total lectures (Including guest lecture) :   28h
                                                                                                              Tutorials :      6h
                                                         CA, student presentations and revision :    18h
  Total hours:      52h
 
 
MAIN REFERENCES: Selected papers
 
SUPPLEMENTARY TEXT BOOKS:
(1) Genes VII (Lewin)
(2) Molecular Biology of the Cell (6th Edition by Alberts, Johnson, Lewis, Morgan, Raff, Roberts & Walter; Publisher: Garland Science)
MODES OF ASSESSMENT:
50% CA (1 x short essay question test, 1 x student presentation)
50% Final Exam (60 x multiple choice questions, closed book)
 
MODULE COORDINATOR:       
Dr. Chen Zhi Xiong                   (Tel: 6516-3231, Email: phscz@nus.edu.sg)
 
LECTURERS:                          
Assoc. Prof. Low Boon Chuan    (Tel: 6516-7834, Email: dbslowbc@nus.edu.sg)
Assoc. Prof. Reshma Taneja      (Tel: 6516-3236, Email: phsrt@nus.edu.sg)
Assoc. Prof. Marius Sudol          (Tel: 6516-5460, Email: phsms@nus.edu.sg)
Prof. Shazib Pervaiz                  (Tel: 6516-6602, Email: phssp@nus.edu.sg)
 
GUEST LECTURER:
Dr. Tsai Shih-Yin                       (Tel: 6516-7617, Email: phsts@nus.edu.sg)
 

Schedule

TopTIMETABLE FOR SEMESTER I, 2017/2018
 
LSM4232 – ADVANCED CELL BIOLOGY
 
Module Coordinator:  Dr. Chen Zhi Xiong
 
LECTURES: MONDAYS & THURSDAYS
TIME: 1200 – 1400 hrs
VENUE: S1A-0217
 

WK

MONTH

LECTURES / TUTORIALS
MONDAYS THURSDAYS
   0. Aug Orientation Week - No classes (Mon, 7 Aug to Sat, 12 Aug 2017)
  1.  
Aug 14  LBC Lecture 1 17  LBC Lecture 2
  1.  
  21  LBC Lecture 3 24  LBC Lecture 4
  1.  
  28  LBC Lecture 5 31  LBC Journal Discussion
  1.  
Sep 04  LBC Journal Discussion 07  RT Lecture 1
  1.  
  11  RT Lecture 2 14  RT Lecture 3
  1.  
  18  RT Lecture 4 21  TS Guest Lecture
Recess week: Sat, 23 Sep – Sun, 1 Oct 2017  (1 week)
  1.  
Oct 02  LBC CA1 05  LBC CA1 Post Mortem
  1.  
  09  RT Student Journal Presentation 12  RT Student Journal Presentation
  1.  
  16  MS  Lecture 1 19  MS Lecture 2
  1.  
  23  MS Student Journal Presentation 26  MS Student Journal Presentation
  1.  
Oct/Nov 30  SP Lecture 1  02  SP Lecture 2
  1.  
  06  SP Student Journal Presentation 09  SP Student Journal Presentation
  1.  
  13  Self-Revision and Consultation 16  Self-Revision and Consultation
READING PERIOD: Sat, 18 Nov to Fri, 24 Nov 2017 (1 week)
EXAMINATION: Mon, 4 Dec 2017, 5pm
VACATION: Sun, 10 Dec 2017 to Sun, 14 Jan 2018 (5 weeks)
 
 Lecturers:
Assoc. Prof. LOW Boon Chuan (dbslowbc@nus.edu.sg; Tel: 6516-7834) (LBC)
Assoc. Prof. Reshma TANEJA (phsrt@nus.edu.sg; Tel: 6516-3236) (RT)
Dr. TSAI Shih-Yin (phsts@nus.edu.sg; Tel: 6516-7617) (TS)
Assoc. Prof. Marius SUDOL (phsms@nus.edu.sg; Tel: 6516-5460) (MS)
Prof. Shazib PERVAIZ (phssp@nus.edu.sg; Tel: 6516-6602) (SP)
 
Coordinator:
Dr. CHEN Zhi Xiong (zhixiong_chen@nus.edu.sg; Tel: 6516-3231)
 
 

Assessment

Top

50% CA (1 x short essay question test, 1 x student presentation)
50% Final Exam (60 x multiple choice questions, closed book)
 

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