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Learning Outcomes

TopThis module will explore the changes that occur in human cells as they grow, mature, differentiate, and either commit to cell death or renew themselves. Insights into the mechanisms that govern the various developmental alterations that occur will be discussed. Emphasis will be placed on understanding the cellular and molecular mechanisms that lend themselves to experimental manipulation.

Prerequisites

TopPrerequisite: LSM2103

Teaching Modes

TopLectures, Tutorials, Group Activity, Journal Discussions and Student Presentations

Syllabus

TopSEMESTER I
LSM4232 ADVANCED CELL BIOLOGY

Prerequisite: LSM2103
Workload: 30 lecture hours + 8 tutorial hours + 10 hours for CA, student presentations and revision
This module will explore the changes that occur in human cells as they grow, mature, differentiate, and either commit to cell death or renew themselves. Insights into the mechanisms that govern the various developmental alterations that occur will be discussed. Emphasis will be placed on understanding the cellular and molecular mechanisms that lend themselves to experimental manipulation.

S/N	Topics	Lecture Hrs
1.	Cell Dynamics Control Morphogenesis, Differentiation and Development Small GTPases and their regulators as major cellular switches Cytoskeletal networks Interplay in cell morphogenesis, cell motility, cell division, organogenesis and development	10 Low Boon Chuan
2.	Cell differentiation - mechanisms Embryonic and postnatal myogenesis Differentiation of skeletal muscle Stem cells and Notch signalling in adult myogenesis and ageing Muscle degeneration mechanisms in muscular dystrophies	10 Reshma Taneja
3.	WW Domain and Hippo-YAP Pathway	4 Marius Sudol
4.	Signalling and ROS in ageing and disease Oxidative stress and mitochondrial ageing DNA Proteins Regulation of cell death signalling Receptor and non-receptor death signalling ROS, KRAS and drug discovery	4 Shazib Pervaiz
	Total lectures (Including guest lecture) : 28h Tutorials : 6h CA, student presentations and revision : 18h
	Total hours:	52h

MAIN REFERENCES: Selected papers

SUPPLEMENTARY TEXT BOOKS:
(1) Genes VII (Lewin)
(2) Molecular Biology of the Cell (6^th Edition by Alberts, Johnson, Lewis, Morgan, Raff, Roberts & Walter; Publisher: Garland Science)
MODES OF ASSESSMENT:
50% CA (1 x short essay question test, 1 x student presentation)
50% Final Exam (60 x multiple choice questions, closed book)

MODULE COORDINATOR:
Dr. Tsai Shih-Yin                      (Tel: 6516-7617, Email: phsts@nus.edu.sg)
Dr. Chen Zhi Xiong                  (Tel: 6516-3231, Email: phscz@nus.edu.sg)

LECTURERS:
Assoc. Prof. Low Boon Chuan (Tel: 6516-7834, Email: dbslowbc@nus.edu.sg)
Assoc. Prof. Reshma Taneja    (Tel: 6516-3236, Email: phsrt@nus.edu.sg)
Assoc. Prof. Marius Sudol        (Tel: 6516-5460, Email: phsms@nus.edu.sg)
Prof. Shazib Pervaiz                (Tel: 6516-6602, Email: phssp@nus.edu.sg)

Schedule

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TIMETABLE FOR SEMESTER I, 2018/2019

LSM4232 – ADVANCED CELL BIOLOGY
Module Coordinator: Dr Tsai Shih-Yin
Email: phsts@nus.edu.sg
Tel: 6516 7617

Lectures:	Tuesdays	Lectures:	Fridays
Time:	1200 – 1400 hrs	Time:	1600 – 1800 hrs
Venue:	LT32	Venue:	LT32

Wk	Month	Lectures / Tutorials
Wk	Month	Tuesdays	Fridays
	Orientation Week: Mon, 6 Aug – Sat, 11 Aug 2018 (No lecture)
1.	Aug	14 LOW Boon Chuan Lecture 1	17 LOW Boon Chuan Lecture 2
2.		21 LOW Boon Chuan Lecture 3	24 LOW Boon Chuan Lecture 4
3.		28 LOW Boon Chuan Lecture 5	31 LOW Boon Chuan Journal discussion
4.	Sep	04 LOW Boon Chuan Journal discussion	07 Reshma TANEJA Lecture 1
5.		11 Reshma TANEJA Lecture 2	14 Reshma TANEJA Lecture 3
6.		18 Reshma TANEJA Lecture 4	21 Reshma TANEJA Lecture 5
	Recess Week: Sat, 22 Sep – Sun, 30 Sep 2018 (1 week)
7.	Oct	02 LOW Boon Chuan CA1	05 LOW Boon Chuan CA1 Post Mortem
8.		09 Reshma TANEJA Journal Presentation	12 Reshma TANEJA Journal Presentation
9.		16 Marius SUDOL Lecture 1	19 Marius SUDOL Lecture 2
10.		23 Marius SUDOL Journal Presentation	26 Marius SUDOL Journal Presentation
11.	Oct/Nov	30 Shazib PERVAIZ Lecture 1	02 Shazib PERVAIZ Lecture 2
12.	Nov	06 Deepavali (Public Holiday)	09 Shazib PERVAIZ Journal Presentation
13.		13 Shazib PERVAIZ Journal Presentation	16 Self-Revision and Consultation
	Reading Week: Sat, 17 Nov – Fri, 23 Nov 2018 (1 week)
	Examination: Fri, 30 Nov 2018 2:30 pm
	Vacation: Sun, 9 Dec 2018 – Sun, 13 Jan 2019 (5 weeks)

Lecturers:
Prof Shazib Pervaiz (phssp@nus.edu.sg; Tel: 6516-6602) (SP)
A/P Low Boon Chuan (dbslowbc@nus.edu.sg; Tel: 6516-7834) (LBC)
A/P Marius Sudol (phsms@nus.edu.sg; Tel: 6516-5460) (MS)
A/P Reshma Taneja (phsrt@nus.edu.sg; Tel: 6516-3236) (RT)

Coordinator:
Dr Tsai Shih-Yin (phsts@nus.edu.sg; Tel: 6516-7617) (TS)

Co-coordinator:
Dr Chen Zhi Xiong (zhixiong_chen@nus.edu.sg; Tel: 6516-3231)

Assessment

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