MEDICAL MYCOLOGY AND DRUG DISCOVERY
2018/2019, Semester 2
Yong Loo Lin School of Medicine (Biochemistry)
Modular Credits: 4
With the growing aging population and number of immuno-compromised patients, fungal infections are increasingly becoming relevant. This module will re-examine Koch’s postulates in relation to the roles opportunistic and primary fungal pathogens play in mycoses. Issues surrounding the molecular, physiological and biochemical aspects of fungal cells that make them successful microbial pathogens will be discussed. Key mechanisms of anti-fungal resistance in relation to challenges facing the discovery of new therapeutics will be examined. Students will have the opportunity to design and conduct a typical drug-susceptibility screen and drug discovery process.
With regards to content knowledge, at the end of the module, students should be able to:
Relate the molecular, physiological and biochemical aspects of fungal biology to pathogenesis;
Describe the molecular interactions between fungal and host cell cells;
Discuss the various types of anti-fungal resistance and why they are problematic;
Evaluate the current strategies of drug discoveries.
With regards to competency skills, at the end of the module, students should be able to:
Critically evaluate and discuss scientific literature and data;
Structure scientific arguments;
Design and execute a small independent laboratory project;
Manage project timelines;
Make effective project presentations.
LSM2233 or LSM2252 or LSM2291
Workload Components : A-B-C-D-E
A: no. of lecture hours per week
B: no. of tutorial hours per week
C: no. of lab hours per week
D: no. of hours for projects, assignments, fieldwork etc per week
E: no. of hours for preparatory work by a student per week